et al. As highlighted above, one key advantage of moxidectin over ivermectin is that it might be effective against ivermectin- resistant S. stercoralis. van Lieshout Moxidectin, a well-established drug in veterinary medicine under consideration for regulatory submission for the treatment of onchocerciasis, might serve as an alternative to the widely used ivermectin. Thirty-two mixed-breed ponies ranging in age from one to 21 years were used in this controlled test. A hard copy of the forms was also completed during data collection and used to cross-check 10% of the electronically collected data. YQ 1995 Oct;59(3-4):241-8. doi: 10.1016/0304-4017(94)00762-2. Therefore, the lower limit of the 95% CI exceeds the preset noninferiority margin of 7 percentage points. . Furtek . Considering the moderate effect of moxidectin against hookworm and the moderate efficacy of albendazole against S. stercoralis together with the similar distribution of these parasites, the combination might be effective in tackling the mentioned infections, while potentially delaying drug resistance. Similarly, moxidectin as pour-on or oral formulation demonstrated a high efficacy against gastrointestinal nematodes in beef cattle [36]. T Su Statistically significantly higher percentages of participants treated with 8 mg moxidectin than participants treated with ivermectin experienced pruritus (87% vs. 56%), rash (63% vs. 42%), increased pulse rate (61% vs. 36%) and decreased mean arterial pressure upon 2 minutes standing still after ≥5 minutes supine relative to pre-treatment (61% vs. 27%). Marcotty J Abbreviations: AM, arithmetic mean; CI, 95% confidence interval; EPG, eggs per gram; GM, geometric mean. Two weeks following treatment, necropsy examinations of all animals were performed. YY Dobson CRs were calculated as the percentage of participants who became larvae-negative after treatment, being larvae positive at baseline. Of note, we did not distinguish the activity against different hookworm species, including Ancylostoma ceylanicum, which is common in the study area [31] and should be evaluated in follow-up studies. TM Conlan RJ Z . Safety and efficacy against coinfections with soil-transmitted helminths and Opisthorchis viverrini were secondary outcomes. ERRs were calculated using the following formula: ERR = [1 – (geometric mean at follow-up/geometric mean at baseline)] × 100. A Pankavich We acknowledge the support of technical staffs from the Centre for Malariology, Parasitology and Entomology, Department of Parasitology, University of Health Sciences, Ministry of Health, Vientiane, Champasack Provincial Malaria station, who helped with the stool sample examinations and Champasack Provincial Health Department and Pathoumphone District Health Office for their collaboration and support. Pipitgool As reported in the literature, ivermectin was well tolerated, with a similar number of side effects observed in the ivermectin and placebo groups [23–25]. Members of replicates were allocated to one of four treatment groups: moxidectin oral gel administered at 300 micrograms kg-1 body weight, moxidectin oral gel at 400 micrograms kg-1, the oral gel vehicle as negative control, and ivermectin oral paste at 200 micrograms kg-1. XX Acknowledgments. A class of drugs commonly used in veterinary medicine include ivermectin, milbemycin, and moxidectin; these are anthelmintics (these drugs kill parasites) and are commonly used as an active ingredient for monthly heartworm preventatives.Certain breeds of dogs (e.g., collies, Border collies, Australian shepherds, Old English sheepdogs, etc.) When it comes to scabies treatment, permethrin and ivermectin are both associated with high clearance rates. Eight weeks prior to the experiment, ponies grazing on contaminated pasture were moved to a paddock and fed a pelleted ration, thus reducing or eliminating the potential for additional infection and ensuring the existence of a population of encysted larvae. Please check for further notifications by email. Once a filled stool container arrived at the research station, a research team member scanned the attached barcode for sample registration and subsequently the system automatically generated a specific form for further data entry. PT Correspondence: J. Keiser, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P.O. A recent study that used the same formulation of moxidectin in children infected with Schistosoma mansoni and Schistosoma haematobium reported mild side effects including nausea, headache, and abdominal discomfort [26]. Katz Parkin NIH All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. . Hayashi 2009 Sep 25;2 Suppl 2(Suppl 2):S1. All authors: No potential conflicts of interest. Infections with Strongyloides stercoralis are of considerable public health relevance. Pors Taisayavong Anthelmintic resistance in equine nematodes. The role of diffusion tensor imaging and tractography in the surgical management of brainstem gliomas. Barnes This is the first randomized trial to assess the efficacy of moxidectin against S. stercoralis infection, which is a neglected yet considerable public health problem. Enrolled participants were randomly allocated to the following 2 treatment arms: ivermectin 200-µg/kg single dose or moxidectin 8-mg single dose. et al. et al. Analyses were performed with Stata (version 12.1). CRs against hookworm infection were 57% (moxidectin) and 56% (ivermectin). Akkavong of 93.7% (59/63) for moxidectin compared to 95.2% (59/62) for ivermectin. Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach. 2014 Oct 25;4(3):310-5. doi: 10.1016/j.ijpddr.2014.10.003. Prior to treatment, ponies were confined in pairs to covered concrete runs by treatment group. Your comment will be reviewed and published at the journal's discretion. Please seek veterinarian advice for foals, young horses, ponies and minis. After fieldwork, data was downloaded from the server into Excel (version 2011). Sutra Only participants positive for the infection were included in the study. Bhumimuang Beknazarova CI Y P Stomach Worms: Intestinal Worms Bankrupt Worms: Nodular Worms Liver Flukes: Tapeworms Roundworms: Kidney Worms Eyeworms: Sucking Lice Biting Lice: Mange Mites Horn Flies Todisco G(1), Paoletti B, Giammarino A, Manera M, Sparagano OA, Iorio R, Giannella B, Robbe D. Author information: (1)Department of Veterinary Clinical Sciences, University of Teramo, Teramo, Italy. Dose titration of moxidectin oral gel against gastrointestinal parasites of ponies. Speich Marti Two dosages of moxidectin oral gel were evaluated and compared to a therapeutic dose of ivermectin oral paste in the control of a spectrum of gastrointestinal parasites of ponies naturally infected in southern Louisiana or Mississippi. Dobson . However, this number had to be increased since the proportion of participants who provided 2 stool samples was lower than expected. et al. This study was supported by the European Research Council (ERC-2013-CoG 614739-A_HERO). Safety, CR, and egg reduction rate (ERR) against coinfections with STHs and O. viverrini were the secondary outcomes. Zhang 105 The exclusion of moxidectin was addressed in a final rule amending the National List (NOP, 2007b). Schär Wen eCollection 2020.  |  Current Controlled Trials: ISRCTN11983645. These drugs are neurotoxic to parasites by potentiating … CRs were 17.8% (10/56; 95% CI, 11.2% to 32.2%; moxidectin) and 6.5% (3/46; 95% CI, 6.4% to 25.4%; ivermectin) with corresponding ERRs of 12.5% (95% CI, –2% to 30%) and 0% (95% CI, –40% to 2%; Table 2). EH Marti Levecke None of the participants reported any side effect from treatment at any time point. As highlighted above, one key advantage of moxidectin over ivermectin is that it might be effective against ivermectin- resistant S. stercoralis. Flow chart of the study conducted in the villages of Morphu and Phakpheo in Champasack Province, Lao People’s Democratic Republic, between April 2016 May 2016. The sample size was increased to 60 per arm to account for a potential loss to follow-up of 15%. G et al. Moreover, moxidectin at recommended dosages was shown to be effective against ivermectin-resistant parasites as well as several macrocyclic lactone–resistant parasites [27]. LF E Rate of 1.25 lbs per 1,250 lbs body weight (1 lb per 1,000 lbs); For ascarids, use 2 - 1.25 lb packets per 1,250 lbs body weight (1 lb per 500 lbs) Geometric and arithmetic mean egg counts were calculated for each group before and after treatment for O. viverrini and STHs infections. Hattendorf The drug might offer some advantages over ivermectin. Moxidectin might be a safe and efficacious alternative to ivermectin for the treatment of S. stercoralis infection, given that only slight differences in CRs were observed. CYDECTIN® Pour-On Moxidectin 28-42 days X X X X X X X X X X Do not use in calves to be processed for veal. LY C Since the mode of action of both drugs is similar, we assumed a CR of 98% for both drugs. ZH The mean estimates of CL/F of moxidectin and ivermectin were 0.0220 +/- 0.00381 and 0.0498 +/- 0.0179 l/h/kg, respectively. Ivermectin is highly effective against S. stercoralis infection, characterized by a high cure rate (CR). Olsen No deviations from the treatment protocol were observed; therefore, the available case analysis is identical with the per-protocol analysis. Despite the high efficacy and safety of ivermectin, which is the current drug of choice, it is crucial to develop and find alternative treatments in case ivermectin resistance arises. P H Sripa Oral moxidectin has a persistent efficacy of up to 5 wk for Haemonchus contortus and Teladorsagia circumcincta. Paraud Le Jambre USA.gov. 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